Pair Name	Astaxanthin, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Tumor angiogenesis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Phosphorylation	JAK2	hsa3717
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	BNIP3	hsa664
	Up-regulation	Expression	HIF1A	hsa3091
	Down-regulation	Expression	EGLN1	hsa54583
	Up-regulation	Phosphorylation	VHL	hsa7428
In Vivo Model	This experiment was performed using the H22 tumor-bearing mousemodel and the Hepa1-6 tumor-bearing mouse model.
Result	Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment